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A fast-mimicking diet may be key in the regeneration of insulin-producing cells in type 1 diabetics

We have already talked about the importance of feeding in people who have autoimmune diseases such as type 1 diabetes. Meanwhile, promising advances for their cure, such as DIAGNODE research, are looking for an immune alternative for regeneration natural insulin.

A new research, published last February, reminds us again of the importance of the diet plan in people with this type of disease, this time through a work that concludes: a diet that imitates fasting can be key in the regeneration of insulin-producing cells in type 1 diabetics.

Some time ago we did a scientific review of the possibilities offered by certain dietary plans in autoimmune diseases such as type 1 diabetes. We saw how low-carbohydrate diets could be a useful and beneficial option for diabetics, and so positioned the ADA ( American Diabetes Association) in its latest reviews : scientific evidence concluded that monitoring of restrictive diets in HC could be an effective measure in people with diabetes.

Following the path of feeding, the latest study published in Cell Press, offers a new alternative approach for the regeneration of damaged pancreatic beta cells and their function of creating insulin.

A diet that mimics fasting can reverse diabetes and improve other autoimmune diseases

The study concludes that an eating plan that mimics fasting, through formulas such as the Miminging Fasting Diet (FMD), could be the key to the regeneration of pancreatic insulin-producing cells in both type 1 and type 2 diabetes patients .

“Fasting can be a practical way for a healthy metabolic system”

The study, recently published by Cell , analyzed the response in a group of rodents, which highlighted a remarkable reversal of the disease in groups that followed a FMD four days a week . All of them regained insulin production capacity, stabilized their blood glucose levels, and reduced their own resistance to insulin.

Three answers more than hopeful through a diet plan that imitates fasting and that previously, found benefits in research that analyzed autoimmunity and regeneration in diseases such as multiple sclerosis.

Also, other research published in Science Translational Medicine concluded that a fast-mimicking diet, by tracking 71 participants who practiced this protocol five days a month over a three-month time frame, decreased not only markers for diabetes, and cancer, but also blood pressure and IGF-1 hormones, implicated in aging and cardiovascular disease, concluding that “fasting can be a practical path to a healthy metabolic system.”

Increased insulin generation in diabetic patients

To conclude this latest analysis, the researchers simulated diabetes in rodents, through high doses of the drug streptozotocin (STZ), which attacked the beta cells of the insulin producing pancreas, thus verifying that genes normally active in the developing pancreas were reactivated in the diabetic adults who followed FMD diets, resulting in new and healthy insulin-producing beta cells.

Visual representation of how an FMD diet modulates the number of B cells and promotes insulin secretion and glucose homeostasis.

The study also focused on human donors with type 1 diabetes , through cultures of their pancreatic cells, resulting in those who followed an FMD diet increased Ngn3 protein and insulin production.

“These findings justify a larger trial by the FDA [the US Food and Drug Administration] on the use of FMD to treat diabetic patients.”

In addition, according to Dr. Longo, in a statement to Europa Press, “hopefully, people with diabetes could be treated one day with an FDA-approved diet that mimics fasting for a few days each month, eating a normal diet during the rest of the month and seeing positive results in their ability to control their blood sugar by producing normal levels of insulin and improving the function of insulin.”


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